Title: A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance
نویسندگان
چکیده
Classification: Biological Sciences Authors: Bingsen Zhou, Leila Su, Shuya Hu, Weidong Hu , M. L. Richard Yip, Jun Wu, Shikha Gaur*, D. Lynne Smith*, Yate-Ching Yuan, Timothy W. Synold, David Horne, and Yun Yen Affiliations: *Department of Molecular Pharmacology, Department of Molecular Medicine, Department of Immunology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010 U.S.A.
منابع مشابه
A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells. The current clinically established RNR inhibitors have the shortcomings of short half-life, drug resistance, and iron chelation. Here, we report the development of a novel class of effective RNR inhibitors addressing t...
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Tamoxifen is widely used as an adjuvant therapy for patients with estrogen receptor (ERα)-positive tumors. However, the clinical benefit is often limited because of the emergence of drug resistance. In this study, overexpression of ribonucleotide reductase M2 (RRM2) in MCF-7 breast cancer cells resulted in a reduction in the effectiveness of tamoxifen, through downregulation of ERα66 and upregu...
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Ribonucleotide reductase catalyzes the rate-limiting step in the de novo synthesis of 2'-deoxyribonucleoside 5'-triphosphates that is required for DNA replication. The mammalian enzyme consists of two nonidentical protein subunits that are both required for enzyme activity. In leukemia L1210 cells, enriched in G1-phase cells by centrifugal elutriation, it was found that ribonucleotide reductase...
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تاریخ انتشار 2013